Bone Regeneration

Segmental bone defects, particularly in injured military personnel and the aging population, reduce health-related quality of life and result in significant healthcare costs. KeraNetics™ is developing a controlled release carrier system capable of providing physiologically relevant doses of bone growth factors.  

In pre-clinical models, this system has demonstrated superior bone repair and regeneration compared to currently available treatments. For example, the delivery vehicle for bone growth factor showed improved released kinetics compared to market leaders. In addition, degradation rates and release profiles can be tailored to match a variety of regenerating bone types.

 Relevant Publications

 Effects of Tunable Keratin Hydrogel Erosion on Recombinant Human Bone Morphogenetic Protein 2 Release, Bioactivity, and Bone Induction

 Biomaterials for the Delivery of Growth Factors and Other Therapeutic Agents in Tissue Engineering Approaches to Bone Regeneration

 Reduction of ectopic bone growth in critically-sized rat mandible defects by delivery of rhBMP-2 from keratin biomaterials