Muscle Reinforcement

Supports Soft Tissue Where Weakness Exists

Injuries to soft tissues can be debilitating and potentially disfiguring. In order to enable functional recovery, KeraNetics, along with experts in the field of regenerative medicine, is developing treatment strategies that involve the delivery of cells and/or factors to muscle injuries. KeraNetics is developing a void filler for volumetric muscle loss as well as several biocompatible delivery vehicles that provide a structural matrix for cell attachment. Pre-clinical models show it is a permissive matrix for cell attachment and proliferation. Additionally, the models found it to be an effective delivery vehicle for growth factors as a matrix or a hydrogel with various porosities.

Relevant Publications

Keratin Hydrogel Enhances In Vivo Skeletal Muscle Function in a Rat Model of Volumetric Muscle Loss

Cell and Growth Factor-Loaded Keratin Hydrogels for Treatment of Volumetric Muscle Loss in a Mouse Model

Keratin hydrogel carrier system for simultaneous delivery of exogenous growth factors and muscle progenitor cells

Tunable Keratin Hydrogels for Controlled Erosion and Growth Factor Delivery